Generic Name: trandolapril and verapamil (tran DOL a pril and ver AP a mil)
Brand Names: Tarka
What is trandolapril and verapamil?
Trandolapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme.
Verapamil is a calcium channel blocker. It works by relaxing the muscles of your heart and blood vessels.
The combination of trandolapril and verapamil is used to treat high blood pressure (hypertension).
Trandolapril and verapamil may also be used for purposes not listed in this medication guide.
What is the most important information I should know about trandolapril and verapamil?
Do not use trandolapril and verapamil if you are pregnant. It could harm the unborn baby. Stop using this medication and tell your doctor right away if you become pregnant. You should not use this medicine if you have certain serious heart problems, or if you are allergic to trandolapril (Mavik) or similar medicines such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or ramipril (Altace).
There are many other drugs that can interact with trandolapril and verapamil. Tell your doctor about all medications you use.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
What should I discuss with my healthcare provider before taking trandolapril and verapamil?
You should not use this medicine if you are allergic to trandolapril (Mavik) or verapamil (Calan, Covera, Isoptin, Verelan), or if you have:
certain serious heart conditions, especially "sick sinus syndrome" or "AV block" (unless you have a pacemaker);
a heart rhythm disorder;
low blood pressure; or
if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), or ramipril (Altace).
To make sure you can safely take trandolapril and verapamil, tell your doctor if you have any of these other conditions:
kidney disease (or if you are on dialysis);
liver disease;
congestive heart failure;
diabetes;
a nerve-muscle disease such as muscular dystrophy; or
a connective tissue disease such as Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.
FDA pregnancy category D. Do not use trandolapril and verapamil if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Trandolapril and verapamil can cause injury or death to the unborn baby if you take the medicine during your second or third trimester. Use effective birth control while taking trandolapril and verapamil. Trandolapril and verapamil can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using trandolapril and verapamil.
How should I take trandolapril and verapamil?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Trandolapril and verapamil works best if you take it with food.
Your blood pressure will need to be checked often. Visit your doctor regularly.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking trandolapril and verapamil. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting. If you need surgery, tell the surgeon ahead of time that you are using trandolapril and verapamil.
Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
See also: Trandolapril and verapamil dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include slow heart rate, weak pulse, muscle weakness, tingly feeling, seizure (convulsions), feeling light-headed, or fainting.
What should I avoid while taking trandolapril and verapamil?
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Do not use salt substitutes or potassium supplements while taking trandolapril and verapamil, unless your doctor has told you to.
Trandolapril and verapamil side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
urinating less than usual or not at all;
swelling, weight gain, feeling short of breath;
feeling like you might pass out;
anxiety, sweating, pale skin, severe shortness of breath, wheezing, gasping for breath, cough with foamy mucus;
chest pain, fast, slow, or uneven heart rate; or
fever, upper stomach pain, and jaundice (yellowing of the skin or eyes).
Less serious side effects may include:
cough;
headache;
runny or stuffy nose, sore throat;
constipation, diarrhea;
dizziness;
back pain;
joint pain; or
nausea.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Trandolapril and verapamil Dosing Information
Usual Adult Dose for Hypertension:
Initial dose: The initial dosage of trandolapril-verapamil recommended for this patient should be based on this patient's requirements for each drug. The usual recommended dosage range for hypertension for trandolapril and verapamil (sustained-release) is 1 to 4 mg (trandolapril) and 120 to 480 mg (verapamil) per day.
What other drugs will affect trandolapril and verapamil?
Many drugs can interact with trandolapril and verapamil. Below is just a partial list. Tell your doctor if you are using:
buspirone (BuSpar);
colchicine (Colcrys);
cyclosporine (Neoral, Sandimmune, Gengraf);
dexamethasone (Cortastat, Dexasone, Solurex, DexPak);
digoxin (digitalis, Lanoxin);
gold injections (to treat arthritis);
lithium (Lithobid, Eskalith);
phenobarbital (Solfoton) or other barbiturates;
insulin or oral diabetes medication;
sirolimus (Rapamune) or tacrolimus (Prograf);
St. John's wort;
theophylline (Elixophyllin, Respbid, Theo-Dur, and others);
an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), rifampin (Rifadin, Rifater, Rifamate) and others;
antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
aspirin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn, Naprelan, Treximet), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), indomethacin (Indocin), meloxicam (Mobic), and others;
a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others;
a diuretic (water pill);
drugs to treat high blood pressure or a prostate disorder, such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), terazosin (Hytrin), tamsulosin (Flomax);
cholesterol-lowering drugs such as atorvastatin (Lipitor, Caduet), lovastatin (Mevacor, Altoprev, Advicor), or simvastatin (Zocor, Simcor, Vytorin, Juvisync);
heart rhythm or blood pressure medication such as disopyramide (Norpace), flecainide (Tambocor), nicardipine (Cardene) or quinidine (Quin-G);
HIV or AIDS medication; or
seizure medication such as carbamazepine (Carbatrol, Equetro, Tegretol), phenytoin (Dilantin), and others.
This list is not complete and there are many other drugs that can interact with trandolapril and verapamil. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More trandolapril and verapamil resources
- Trandolapril and verapamil Side Effects (in more detail)
- Trandolapril and verapamil Dosage
- Trandolapril and verapamil Use in Pregnancy & Breastfeeding
- Trandolapril and verapamil Drug Interactions
- Trandolapril and verapamil Support Group
- 5 Reviews for Trandolapril and verapamil - Add your own review/rating
Compare trandolapril and verapamil with other medications
- High Blood Pressure
Where can I get more information?
- Your pharmacist can provide more information about trandolapril and verapamil.
See also: trandolapril and verapamil side effects (in more detail)
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